Lacey Coppage scored 16 points and Gabby D'Ercole scored 14 to lead Penfield, which captured the Monroe County Division I championship as well as the top seed for the Section V Class AAA tournament.
Colleen Coon added 12 rebounds and seven points and D'ERcole hit four 3-pointer for the Patriots.
Megan Malloy came off the bench and had five points and five assists for the Patriots (16-0), which last won the leage championship in 2004.
PENFIELD: Lacey Coppage 16, Gabby D'Ercole 14, Colleen Coon 7, Colleen Mahany 2, Sarah Tranelli 0, Megan Malloy 5, Monica Nesselbush 4, Laura Wilkins 1, Colleen Lynd 4, Emma Morsch 1, Laura McNamara 2, Ashley Mancuso 0, Meredith Russell 0.
3-point goals: D'ercole 4, Malloy.